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    Amber guidance for IBD in children (azathioprine) Azathioprine PIL for IBD Azathioprine: patient information leaflet - children and young people with rheumatological conditions Azathioprine-Mercaptopurine PIL for IBD LTHT Medication Safety Alert (June 17) - patients with underlying cardiac disease - practical guidance MHRA Drug Safety Update (Feb 17): risk of serious adverse effects in patients with underlying cardiac disease National Paediatric IV Administration Guide (Medusa) - hyoscine butylbromide Amber Drug Guidance: Mercaptopurine for IBD Azathioprine-Mercaptopurine PIL for IBD Patient information leaflet: mercaptopurine for inflammatory bowel disease in children and young people UK guidelines: IBD in children Amber Drug Guidance: Inflammatory Bowel Disease in Children Aminosalicylates-5-asas PIL for IBD Mesalazine Foam Enema PIL for IBD Mesalazine Liquid Enema PIL for IBD Mesalazine oral PIL for IBD Mesalazine suppositories PIL for IBD UK Guidelines: IBD in children Amber Level 1- Specialist Recommendation These medicines are considered suitable for GP prescribing following specialist recommendation. There is no requirement for full Amber Drug Guidance. Generic Amber Level 1 Drug Guidance detailing responsibilities and information sources is available here Amber Level 2- Specialist Initiation but no monitoring requirements These medicines are considered suitable for GP prescribing following specialist initiation, including titration of dose and assessment of efficacy. Some Amber Level 2 products will have an associated Amber Level 2 Drug Guidance document, available by clicking on the traffic light symbol to the right of the drug name. If this is not available, generic Amber Level 2 Drug Guidance is available here Amber Level 3- Specialist Initiation with ongoing monitoring requirements (Full Amber Drug Guidance required) Medicines that should be initiated by a specialist, and which require significant monitoring on an ongoing basis. Full agreement to share the care of each specific patient must be reached under the amber drug agreement, and Amber Drug Guidance must be provided to the GP (available by clicking on the traffic light symbol to the right of the drug name). Guidance on the responsibilities for Red Drugs can be found here. QT prolongation Torsades de pointes Alopecia Anaphylactic reactions Angioedema Cholestasis Dizziness Dyspnea Hepatic failure Hepatitis Hypertriglyceridemia Hypokalemia Increased alkaline phosphatase Increased ALT/AST Jaundice Leukopenia Pallor Seizures Stevens-Johnson syndrome Taste perversion Thrombocytopenia Toxic epidermal necrolysis Hypersensitivity to other azoles Use caution in proarrhythmic conditions and renal impairment Use extreme caution or avoid in congenital long-QT patients and patients with conditions that increase QT-prolongation risk Fluconazole inhibits CYP2C9, CYP2C19, and CYP3A4 isoenzymes; coadministration with drugs that are substrates if these isoenzymes may be contraindicated or warrant dosage modifications Capsules contain lactose and should not be given to patients with rare hereditary problems of galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption Powder for oral suspension contains sucrose and should not be used in patients with hereditary fructose, glucose/galactose malabsorption or sucrase-isomaltase deficiency Syrup contains glycerol; may cause headache, stomach upset, and diarrhea Hepatotoxicity reported with use; use with caution in patients with hepatic impairment Rare exfoliative skin disorders reported; monitor closely if rash develops and discontinue if it progresses When driving vehicles or operating machines, it should be taken into account that dizziness or seizures may occasionally occur Candida krusei is inherently resistant Convenience and efficacy of single dose oral tablet of fluconazole regimen for the treatment of vaginal yeast infections should be weighed against acceptability of higher incidence of drug related adverse events with fluconazole (26%) versus intravaginal agents (16%) If drug is used during pregnancy or if patient becomes pregnant while taking the drug, patient should be informed of potential hazard to fetus; effective contraceptive measures should be considered in women of child-bearing potential who are being treated with 400 to 800 mg/day and should continue throughout the treatment period and for approximately 1 week (5 to 6 half-lives) after the final dose Highly selective inhibitor of fungal cytochrome P-450-dependent enzyme lanosterol 14-alpha-demethylase Subsequent loss of normal sterols correlates with accumulation of 14 alpha-methyl sterols in fungi and may be responsible for the fungistatic activity of fluconazole Additive: TMP-SMX Y-site: Amphotericin B, amphotericin B cholesteryl sulfate, ampicillin, calcium gluconate, cefotaxime, ceftazidime(? ), ceftriaxone, cefuroxime, chloramphenicol, clindamycin, co-trimoxazole, diazepam, digoxin, erythromycin lactobionate, furosemide, haloperidol, hydroxyzine, imipenem/cilastatin, pentamidine, piperacillin, ticarcillin, TMP-SMX Solution: D5W, LR Additive: Acyclovir, amikacin, amphotericin B, cefazolin, ceftazidime, ciprofloxacin, clindamycin, gentamicin, heparin, meropenem, metronidazole, morphine, piperacillin, potassium chloride, ranitidine with ondansetron, theophylline Y-site: Acyclovir, aldesleukin, allopurinol, amifostine, amikacin, aminophylline, amiodarone, ampicillin-sulbactam, aztreonam, benztropine, bivalirudin, cefazolin, cefepime, cefotetan, cefoxitin, cefpirome, chlorpromazine, cimetidine, cisatracurium, dexamethasone sodium phosphate, dexmedetomidine, diltiazem, diphenhydramine, dobutamine, docetaxel, dopamine, doxorubicin liposomal, droperidol, etoposide PO4, famotidine, fenoldopam, filgrastim, fludarabine, foscarnet, ganciclovir, gatifloxacin, gemcitabine, gentamicin, granisetron, heparin, hetastarch, hydrocortisone, immune globulin, leucovorin, linezolid, lorazepam, melphalan, meperidine, meropenem, metoclopramide, metronidazole, midazolam, morphine, nafcillin, nitroglycerin, ondansetron, oxacillin, paclitaxel, pancuronium, penicillin G, phenytoin, piperacillin-tazobactam, prochlorperazine, promethazine, propofol, quinupristin-dalfopristin, ranitidine, remifentanil, sargramostim, tacrolimus, teniposide, theophylline, thiotepa, ticarcillin-clavulanate, tobramycin, vancomycin, vecuronium, vinorelbine, zidovudine Tablets: Store below 86° F (30° C) Dry powder: Store below 86° F (30° C); reconstituted suspension should be stored between 86° F (30° C) and 41° F (5° C), and unused portion should be discarded after 2 weeks; protect from freezing Injection (glass bottles): Store between 86° F (30° C) and 41° F (5° C); protect from freezing Injection (Viaflex Plus plastic containers): Store between 77° F (25° C) and 41° F (5° C); protect from freezing The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

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    Tablets 50 mg, 100 mg, 150 mg, 200 mg. Indications and dosages. Oropharyngeal and esophageal candidiasis. Adults 200 mg P. O. or I. V. on day 1 followed by. Schleimhaut-Candidosen, Prophylaxe von Candidosen bei Patienten mit Chemo - oder Radiotherapie, Candidämie, Hautmykosen, Kryptokokken-Meningitis. Solution for Intravenous Infusion. 2 mg/mL Intravenous Infusion. treated with high-dose 400 mg/day to 800 mg/day fluconazole therapy for.

    150 mg orally as a single dose Infectious Diseases Society of America (IDSA) Recommendations: -Uncomplicated vaginitis: 150 mg orally as a single dose -Management of recurrent vulvovaginal candidiasis (after 10 to 14 days induction therapy): 150 mg orally once a week for 6 months -Complicated vulvovaginal candidiasis: 150 mg orally every 72 hours for 3 doses US CDC Recommendations: -Uncomplicated vulvovaginal candidiasis: 150 mg orally as a single dose -Initial therapy for recurrent vulvovaginal candidiasis: 100 to 200 mg orally every 72 hours for 3 doses -Maintenance therapy for recurrent vulvovaginal candidiasis: 100 to 200 mg orally once a week for 6 months -Severe vulvovaginal candidiasis: 150 mg orally every 72 hours for 2 doses US CDC, National Institutes of Health (NIH), and IDSA Recommendations for HIV-infected Patients: -Uncomplicated vulvovaginal candidiasis: 150 mg orally as a single dose -Severe or recurrent vulvovaginal candidiasis: 100 to 200 mg orally once a day for at least 7 days -Suppressive therapy for vulvovaginal candidiasis: 150 mg orally once a week Comments: -Recommended as preferred therapy -Unless frequent or severe recurrences, suppressive therapy generally not recommended Oropharyngeal candidiasis: 200 mg IV or orally on the first day followed by 100 mg IV or orally once a day Duration of therapy: At least 2 weeks, to reduce the risk of relapse IDSA Recommendations: -Moderate to severe oropharyngeal candidiasis: 100 to 200 mg IV or orally once a day for 7 to 14 days Comments: -Recommended as primary therapy US CDC, NIH, and IDSA Recommendations for HIV-infected Patients: -Initial episodes of oropharyngeal candidiasis: 100 mg orally once a day for 7 to 14 days -Suppressive therapy for oropharyngeal candidiasis: 100 mg orally once a day or 3 times a week Comments: -Recommended as preferred oral therapy -Unless frequent or severe recurrences, suppressive therapy generally not recommended Doses up to 400 mg/day have been used. Comments: -Optimal therapeutic dose and therapy duration have not been established. Use: For systemic Candida infections including candidemia, disseminated candidiasis, and pneumonia IDSA Recommendations: Candidemia in nonneutropenic or neutropenic patients: 800 mg IV or orally on the first day followed by 400 mg IV or orally once a day Duration of therapy: -Nonneutropenic patients: 14 days after first negative blood culture and candidemia signs/symptoms resolve -Neutropenic patients: 2 weeks after Candida cleared from bloodstream (documented) and candidemia symptoms and neutropenia resolve Chronic disseminated candidiasis in stable patients: 400 mg IV or orally once a day Duration of therapy: Until lesions have resolved (usually months) and through periods of immunosuppression Candida osteoarticular infection: 400 mg IV or orally once a day Duration of therapy: -Osteomyelitis: 6 to 12 months -Septic arthritis: At least 6 weeks CNS candidiasis (after initial regimen of IV amphotericin B): 400 to 800 mg IV or orally once a day Duration of therapy: Until all signs/symptoms and CSF and radiologic abnormalities resolve Candida cardiovascular system infection: 400 to 800 mg IV or orally once a day Duration of therapy: -Endocarditis: Lifelong suppressive therapy may be indicated. -Pericarditis or myocarditis: Often several months -Suppurative thrombophlebitis: At least 2 weeks after candidemia cleared -Infected pacemaker, implantable cardioverter defibrillator (ICD), or ventricular assist device (VAD): 4 to 6 weeks after device removed; chronic suppressive therapy if VAD not removed Comments: -Candidemia in nonneutropenic patients: Recommended as primary therapy; an echinocandin is recommended for moderately severe to severe illness or recent azole exposure; switching to this drug after initial echinocandin is often appropriate. -Candidemia in neutropenic patients: Recommended as alternative therapy; an echinocandin or IV amphotericin B preferred for most patients; this drug recommended for patients without recent azole exposure and who are not critically ill. -Recommended as primary therapy for chronic disseminated candidiasis in stable patients, Candida osteoarticular infection, CNS candidiasis, pericarditis/myocarditis, and suppurative thrombophlebitis -Recommended as alternative therapy for endocarditis and infected pacemaker, ICD, or VAD Doses up to 400 mg/day have been used. Comments: -Optimal therapeutic dose and therapy duration have not been established. Fluconazole is a first-generation triazole antifungal medication. It differs from earlier azole antifungals (such as ketoconazole) in that its structure contains a triazole ring instead of an imidazole ring. While the imidazole antifungals are mainly used topically, fluconazole and certain other triazole antifungals are preferred when systemic treatment is required because of their improved safety and predictable absorption when administered orally. Fluconazole's spectrum of activity includes most Candida species (but not Candida krusei or Candida glabrata), Cryptococcus neoformans, some dimorphic fungi, and dermatophytes, among others. Common uses include: Fungal resistance to drugs in the azole class tends to occur gradually over the course of prolonged drug therapy, resulting in clinical failure in immunocompromised patients (e.g., patients with advanced HIV receiving treatment for thrush or esophageal Candida infection). albicans, resistance occurs by way of mutations in the ERG11 gene, which codes for 14α-demethylase. These mutations prevent the azole drug from binding, while still allowing binding of the enzyme's natural substrate, lanosterol. glabrata is increasing the rate of efflux of the azole drug from the cell, by both ATP-binding cassette and major facilitator superfamily transporters. Development of resistance to one azole in this way will confer resistance to all drugs in the class. Other gene mutations are also known to contribute to development of resistance.

    Fluconazole iv dose

    Fluconazole Dosage Guide with Precautions -, DIFLUCAN Inf Lös 200 mg/100ml i.v. -

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    IV since oral absorption is rapid and essentially complete--IV. The daily dose of fluconazole for the treatment of infections other than vaginal. Welcome. This NCHD guide is a small web app that will work off line once you have chosen your current hospital. Please "add to home screen" and an icon link will be. UpToDate, electronic clinical resource tool for physicians and patients that provides information on Adult Primary Care and Internal Medicine, Allergy and.

     
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