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    (hypercapnia) that occurs when the respiratory load can no longer be supported by the strength or activity of the system. The most common causes are severe acute exacerbations of asthma and COPD, overdoses of drugs that suppress ventilatory drive, and conditions that cause respiratory muscle weakness (eg, Guillain-Barré syndrome, myasthenia gravis, botulism). Diagnosis is by ABGs and patient observation; chest x-ray and clinical evaluation may help delineate cause. Findings include dyspnea, tachypnea, and confusion. Treatment varies by condition but often includes mechanical ventilation. Hypercapnia occurs when alveolar ventilation either falls or fails to rise adequately in response to increased carbon dioxide production. A fall in alveolar ventilation results from a decrease in minute ventilation or an increase in dead space ventilation without appropriate compensation by increasing minute ventilation. Ventilatory failure can occur when there is excessive load on the respiratory system (eg, resistive loads or lung and chest wall elastic loads) versus neuromuscular competence for an effective inspiratory effort. When the minute ventilation load increases (eg, as occurs in sepsis), a compromised respiratory system may not be able to meet this increased demand (for causes, see Figure: The balance between load (resistive, elastic, and minute ventilation) and neuromuscular competence (drive, transmission, and muscle strength) determines the ability to sustain alveolar ventilation.). Health Tests used to Diagnose Kidney Disease in. Doryx Doxycycline Hyclate Side Effects, Interactions, Warning. Doxycycline Capsules BP 100mg – Summary of Product - eMC
     
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